In an early study Jani et al. administred rutile TiO₂ (500 nm) as a 0.1 ml of 2.5 % w/v suspension (12.5 mg/kg BW) to female Sprague Dawley rats, by oral gavage daily for 10 days and detected presence of particles in all the major gut associated lymphoid tissue as well as in distant organs such as the liver, spleen, lung and peritoneal tissue, but not in heart and kidney. The distribution and toxicity of nano- (25 nm, 80 nm) and submicron-sized (155 nm) TiO₂ particles were evaluated in mice administered a large, single, oral dosing (5 g/kg BW) by gavage. In the animals that were sacrificed two weeks later, ICP-MS analysis showed that the particles were retained mainly in liver, spleen, kidney, and lung tissues, indicating that they can be transported to other tissues and organs after uptake by the gastrointestinal tract. Interestingly, although an extremely high dose was administrated, no acute toxicity was observed. In groups exposed to 80 nm and 155 nm particles, histopathological changes were observed in the liver, kidney and in the brain. The biochemical serum parameters also indicated liver, kidney and cardiovascular damage and were higher in mice treated with nano-sized (25 or 80 nm) TiO₂ compared to submicron-sized (155 nm) TiO₂. However, the main weaknesses of this study are the use of extremely high single dose and insufficient characterisation of the particles.

This white pigment composed of barium sulfate and zinc sulfide, is influenced by several market drivers and trends. One significant driver is the expanding demand for lithopone in the paint and coating industry, owing to its excellent hiding power and (ultraviolet) UV resistance. The construction sector also propels the market growth of this compound, as it is widely used in architectural coatings for its durability and weather resistance. Additionally, the rising popularity of lithopone in the plastic and rubber industries, driven by its ability to enhance product opacity and stability, contributes to market expansion. Trends in this compound market include a growing emphasis on eco-friendly alternatives, stimulating research and development of sustainable production processes. Furthermore, the increasing focus on product quality and performance, along with advancements in nanotechnology applications, presents new opportunities for lithopone market players. Overall, the evolving landscape of industries utilizing this compound underscores its dynamic market, driven by both traditional applications and emerging trends.